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加拿大卡尔加里大学招收分子微生物学访问学者、博士后
  2014-05-18  

The proposed research is on the phylogenetic analysis of Mycobacterium avium subsp. paratuberculosis (MAP), the causative organism of Johne's disease (JD). JD is a debilitating, incurable, chronic enteritis in ruminants that is of great economic impact to the Dairy industry. Our collection of >1000 MAP isolates from dairy herds and >200 (and counting) whole genome sequences has provided us a wealth of information regarding the diversity and phylogeny of MAP in Canada. A PDF with advanced skills in bioinformatics and molecular microbiology will use the epidemiological metadata accompanying the large amounts of genomic data to answer questions related to transmission dynamics, immune responses and pathogenesis. SNPs will be studied that lead to the generation of major clades in the phylogenetic trees to discover reasons for increased transmission potential and virulence. Experimental confirmation of pathophenotypes can be performed using macrophage infections, cytokine measurements, kinomics and in vivo infection models. This project can either lean over to the phylogenetic, molecular epidemiological or molecular microbiology side, but ideally would become a combination of all three. This project will lead to a better understanding of the mechanisms behind increased pathogenicity and competitiveness and what is driving the selection of such strains of MAP.

Send your CV and the names of referees to us fangxuezhuanjia@163.com

卡尔加里大学(University of Calgary)位于加拿大艾伯塔省卡尔加里的西北部,是加拿大前排名前七的研究性大学之一。它的前身是阿尔伯塔大学卡尔加里分校。1966年开始独立授予学生学位。2004年拥有总计27,928名学生,其中来自87个国家的900名国际学生包括中国留学生400名。大学提供100多个学科,可以授予本科、硕士、博士学位。学校还拥有一个医学院,一个商学院,一个法学院,同时计划在2006年建立一个兽医学院。卡大的国际旅游教育与研究中心经世界旅游组织认可,是欧洲之外的仅有的研究中心。在2005年,本来已经是学校里资源最充足的工程系得到了5千万加元的捐款。这个加拿大历史上数目第四大的捐款使工程系改名为Schulich School of Engineering(Schulich 是捐款人的姓名)。

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